Project Number: UMO-2016/22/E/NZ7/00641
Project implemented under the SONATA BIS 6 program
Project title: Nanoparticle antioxidants: biological foundations for potential targeted therapy of neurodegenerative diseases.
Project Promoter: University of Rzeszów
Principal Investigator: Prof. Izabela Anna Sadowska-Bartosz, PhD, DSc, ProfTit
Project Value: 1 668 800,00 PLN
Time of realization: 27.03.2017 – 30.09.2022 (PRz involvement: 21.03.2022 – 30.09.2022)
Project financed by Polish National Science Centre (NCN)
Aim of the Project:
The aim of the project is: (i) synthesis of nano-antioxidants containing nitroxyl free radicals, (ii) analysis of their penetration into cells, (iii) assessment of their toxicity to cells (iv) effectiveness in alleviating oxidative (OS)/nitrative (NS) stress and its effects. The main goal of the project is to test the cytotoxicity and efficacy of two selected covalently bonded nitroxides (NZN) in ameliorating the pathological effects of alterations in animal models of Alzheimer's disease (AD) and Parkinson's disease (PD). The project also aims to analyze in detail the mechanism of involvement of NZN in anti-degenerative protection of nerve cells.
